Top 10 Supplements to Take for Leaky Gut


Leaky gut is also known as “intestinal permeability.” It is a condition where some undigested proteins pass directly into the bloodstream. This occurs when the gateway between the bloodstream and intestines is damaged and allows these particles free access. When the particles escape into the bloodstream, it can cause inflammation body-wide and can also begin an immune response.

If left untreated or unhealed, it can cause food sensitivities, IBS, adrenal fatigue, ADHD, autoimmune disease, arthritis and any number of other problems. Most doctors will tell you it’s difficult to heal and will take some time. But there are 10 supplements that can help when they are made a part of a daily health routine.

  1. Probiotics

High-quality probiotics can greatly improve your gut health. Without a probiotic solution, it’s nearly impossible to cure leaky gut. Be sure to purchase probiotics that have at least 50 billion CFUs.

  1. Fiber

Without having fiber in the system, probiotics are unable to live. Indigestible fiber is the food probiotic bacteria need to thrive in your gut. Foods high in fiber, such as sprouted chia seeds, flaxseeds, or sprouted hemp seeds are important. For those with a very sensitive gut, start with adding steamed veggies to your diet. If you have a gut that is not overly sensitive, try taking in 30 to 40 grams of fiber each day.

  1. Supplemental Enzymes

Two or three capsules of supplemental digestive enzymes taken before and after meals can have a great benefit. Enzymes are useful for helping to break down proteins, starches, and sugars completely. This helps reduce intestinal inflammation.

  1. L-Glutamine

L-glutamine is an essential amino acid and is anti-inflammatory. It also helps repair the intestinal lining and the gut. Cells that line the intestines use glutamine for fuel to help keep the intestines healthy. In particular, they help repair leaky gut syndrome. Stress depletes glutamine levels which leaves you vulnerable to developing leaky gut which makes taking supplemental L-glutamine beneficial for the body.

  1. Licorice Root

Licorice root is an adaptogenic herb that has been proven to be beneficial for increasing hormone levels. It is useful for alleviating adrenal fatigue since it can help absorb and metabolize cortisol. Licorice root is also beneficial for supporting the natural process the body goes through to maintain the mucosal lining in the stomach and duodenum. When leaky gut is caused by emotional stress, it is especially beneficial.

  1. Collagen Powder

Bone broth is powerful due to the collagen it contains. Collagen is the primary proteins that provide strength for cartilage, bone and tendons. After it’s cooked, it turns into “gelatin.” As a supplement, collagen or gelatin can help boost gastric juices and restore the health and integrity of the mucosal lining. Collagen also provides two amino acids, glycine and proline which are essential for repairing a damaged intestinal lining.

  1. N-Acetyl Glucosamine

NAG, or N-acetyl glucosamine is gaining attention because it is becoming known for helping protect the lining of the intestines and stomach. It has an anti-inflammatory effect and has reportedly been effective at helping improve ulcerative colitis, Crohn’s disease and Inflammatory bowel disease.

  1. Quercetin

There are many health benefits from Quercetin as it helps improves the function of the gut barrier since it helps seal the gut lining. It does this by creating tight junction proteins. This is effective for keeping inflammation down. In one sense, it acts like an anti-inflammatory and antihistamine and might even be effective at protecting against cancer and heart disease.

  1. Hydrochloric acid with Pepsin

Hydrochloric acid, or HCL is the primary acid found in the stomach that breaks protein down. This process helps proteins digest more fully before entering the duodenum and intestines. For most people, leaky gut stems from having low stomach acid brought on by antibiotics, birth control pills or other medications. HCL with pepsin is remedy for heartburn and is used when the stomach is not able to produce adequate amounts of hydrochloric acid. Bringing the levels up to the right levels can help heal SIBO and leaky gut.

  1. Anti-Fungal Supplements

For a short term treatment for leaky gut syndrome antifungal agents such as cellulose, oregano oil and caprylic acid can be useful. One cause of leaky gut syndrome is often having the flora imbalanced and having an overgrowth of candida and yeast. Anti-fungals can help balance out the bacteria in the gut, both the good and the bad. This can take enough strain off of your intestines to help them heal and restore the health of the digestive tract. Taking them for about 10-14 days is often enough. After that, use probiotic supplements and eat probiotic rich foods. This helps ensure the rebuilding of your gut health and helps maintain it for the long-term.